luscher brain interneurons control (L) mutant (R)

luscher brain interneurons control (L) mutant (R)

luscher brain interneurons control (L) mutant (R)

Microscope images of SST+ interneurons from a control brain (left) and a mutant brain with the GABA receptor disabled (right). The cells are stained with fluorescent dyes labeling the GABA receptor (green), an associated scaffolding protein (red), and the cell body (blue). Loss of green and red staining in the mutant indicates the loss of GABA inhibition in these cells, which leads to antidepressant activity.

Image: Lüscher laboratory, Penn State University