Antibiotic compound bound to gonorrhea bacteria ribosome

Antibiotic compound bound to gonorrhea bacteria ribosome

cryo-EM image of compound bound to ribosome

A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study. The compound, MBX-4132, binds to the bacterial ribosome and, in so doing, displaces a region of a protein (bL27, purple) that is critical to the trans-translation pathway in bacteria.

IMAGE: Dunham Lab, Emory University