Makova non-B DNA

Makova non-B DNA

Illustration shoing DNA structure impact on syntheis rate and error rate

The speed and error rate of DNA Synthesis differs between regions of the genome that form the usual DNA structure (B DNA) and those regions that can form other structures (non-B DNA). Regions that can form G-quadruplexes (illustrated) slow down DNA synthesis and increase error rates, other non-B DNA structures can have the opposite effect. This phenomenon could help explain increased human genetic variation and increased divergence between human and orangutan at these sites and has implications for understanding cancer and neurological diseases associated with non-B DNA.

IMAGE: Wilfried Guiblet, Penn State