Disrupting two genes involved in the preservation of RNA molecules inhibits the ability of the male form of the malaria parasite to mature and be transmitted from human blood into mosquitoes, according to researchers at Penn State and the University of Florida.
Heartbeat irregularities connected to brain activity abnormalities may lead to the ability to predict eventual epileptic seizures in subjects who suffered physical or infectious brain insults, according to Penn State researchers who studied mouse models of cerebral malaria, which often causes epilepsy in those who survive.
Typhoid Mary may have infected a hundred or more people, but asymptomatic carriers of malaria infect far more people every year through mosquito vectors. An international team of researchers is working toward a way to identify malaria patients including infected individuals who show no malaria symptoms.
Penn State undergraduate student Paige Laughlin has been selected to receive the 2017 Pennsylvania Association of Colleges and Employers' JoAnne Day Student of the Year Award in the technical category.
Researchers have used whole genome analyses and chemogenetics to identify new drug targets and resistance genes in the parasite the causes malaria.
The parasite that causes malaria has not one, but two, specialized proteins that protect its genetic material until the parasite takes up residence in a new host.
Manuel Llinás, professor of biochemistry and molecular biology, and Jason Rasgon, professor of entomology and disease epidemiology, have participated in the formulation of an updated research agenda for global malaria elimination and eradication.
Limiting a much-needed resource could pit pathogens against one another and prevent the emergence of drug resistance, say researchers.
A virus that infects a species of malaria-transmitting mosquito could help scientists gain a better understanding of mosquito biology and eventually could lead to methods for stopping or slowing the spread of the disease, according to a researcher in Penn State's College of Agricultural Sciences. Jason Rasgon, professor of entomology, has received a grant of $1.9 million from the National Institutes of Health to study the virus, called AgDNV.
A new study shows that the infectious agent responsible for malaria, the Plasmodium parasite, is able to sense its host’s nutritional status and actively adapt through changes in gene expression to reduce the number of offspring it produces.
A newly described protein could be an effective target for combating drug-resistant malaria parasites. The protein, the transcription factor PfAP2-I, regulates a number of genes involved with the parasite’s invasion of red blood cells, a critical part of the parasite’s complex life cycle that could be targeted by new anti-malarial drugs.
Researchers at Penn State have received more than $1 million in first-year funding from the National Institutes of Health to investigate malaria transmission in Southeast Asia with a goal of working toward the disease's elimination in the region. They will receive up to approximately $9 million over seven years for this project.
The goal of eliminating malaria in countries like India could be more achievable if mosquito-control efforts take into account the relationship between mosquitoes and cattle, according to an international team of researchers.
Protecting the landscape may also help protect people from some infectious diseases, according to Erica Smithwick, associate professor of geography. Smithwick and her colleagues have been investigating how land use has affected the spread of two diseases in sub-Saharan Africa.
The malaria parasite Plasmodium falciparum hijacks an immune system process to invade red blood cells, according to a study led by researchers at Penn State College of Medicine. Understanding how malaria invades the cells could lead to a more effective vaccine.
