Resolution-canine parvovirus

Resolution-canine parvovirus

images of canine parvovirus before and after treatment with antibodies

Virologist Susan Hafenstein's lab uses cryo-electron microscopy to make high-resolution models of viruses such as the canine parvovirus (CPV) shown here. At left is a CPV capsid, or protein shell, color-coded to indicate surface features. Red areas are depressed and light blue areas are elevated. The capsid at right has been treated with antibodies, shown in dark blue. Binding to the antibodies caused changes in the capsid surface, offering clues to how the virus might be inactivated.

IMAGE: Dan Goetschuis (l) and Lindsey Organtini (r) / Hafenstein Lab