Reese4-2019

Reese4-2019

Illustration of Ccr4-Not role in marking RNAPII for degradation

Ccr4-Not to the rescue. A) Ccr4-Not complex associates with RNA polymerase II (RNAPII) as it travels along a strand of DNA producing RNA. B) When RNAPII becomes stuck due to DNA damage, Ccr4-Not recruits factors that mark RNAPII with a small signaling molecule called ubiquitin. C) Ubiquitylation triggers degradation of RNAPII, allowing DNA repair enzymes to repair the damage and restore gene expression.

IMAGE: Reese Laboratory, Penn State
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