Boal10-2018 Figure

Boal10-2018 Figure

Modified amino acid in metal-free ribonucleotide reductase

A metal-free ribonucleotide reductase—an enzyme required for DNA replication—from bacterial pathogens uses a post-translationally modified amino acid (pictured) to initiate an essential DNA biosynthesis reaction. The modification (indicated by arrow) is essential for initiation of ribonucleotide reduction. This metal-free enzyme could allow microbes associated with strep throat and pneumonia infections to more effectively proliferate during iron/manganese limitation imposed by the human immune system.

IMAGE: Gavin Palowitch, Penn State