kinesin processing

kinesin processing

kinesin walking

Kinesin with vesicle is attached with two "feet" to the cell's microtubule.  This is a safe and stable time period.  The kinesin untethers its back foot and moves it forward.  This is a vulnerable time period when the whole complex could lose its grip.  Finally the loose foot attaches to the microtubule in front and the system is once again stable.

IMAGE: Keith Mickolajczyk / Penn State