microtubules-01

microtubules-01

microtubule line drawing

Model for maintenance of proper microtubule polarity in dendrites.  Polymerizing microtubules entering junctions encounter existing static filaments.  A complex consisting of end-binding protein 1 (EB1) and a kinesin molecular motor binds to the tip of the growing filament and moves along the static filament to co-align the filaments and maintain proper uniform orientation.  The present work demonstrates that an EB1-kinesin complex is able to steer a growing microtubule in this manner without the requirement for any other cellular components.

Image: William Hancock/Penn State
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